Everyone desires a healthy child. However, the genetic causes may shatter their dreams.
Genetic causes are responsible for about 10 percent of recurrent pregnancy losses and
infertility issues. Embryos with an incorrect number of chromosomes may fail to get
implanted or miscarried during the first trimester. According to studies, around 50 to
70 percent of cleavage stage embryos produced in labs can be chromosomally abnormal. The
most common conditions caused by chromosome abnormalities are:
- Down syndrome
- Edwards syndrome
- Patau syndrome
Your fertility doctor may use PGD or PGS techniques to select normal embryos, thus,
resulting in increased implantation rates, reduced spontaneous abortion rates, reduced
aneuploid conceptions, and improved delivery rates in assisted reproductive procedures.
These techniques can be combined with ICSI treatment to tailor infertility treatments to
the unique needs of individual couples when there are concerns about genetic and
What is PGS?
It is a genetic test for identifying abnormalities in chromosomal numbers (aneuploidy).
Your doctor may prescribe PGS before transferring embryos into the uterus. The doctors
selectively transfer the embryos free of chromosomal aneuploidy into the uterus, thus
increasing the chances of successful IVF
How does a PGS work?
PGS analyzes all 46 chromosome types and culls out chromosomally normal embryos. PGS
results in lesser pregnancies ending in miscarriages because of chromosomal disorders
since your doctor identifies abnormalities before embryo transfer.
What are the indications of PGS?
- Age of woman greater than 35 years
- Spontaneous abortion or recurrent pregnancy
- Multiple implantations or IVF failures
- Chromosomal sperm abnormality in males
- Couples with a history of pregnancy with a chromosomal abnormality
- Single embryo transfer
What is PGD?
PGD analyzes embryos during an IVF cycle to detect any genetic alterations. PGD focuses
on single-gene disorders. A PGD can prevent the transfer of single-gene conditions from
one generation to another. Your doctor may prescribe PGD on the embryo before
transferring it into the uterus.
After PGD, a doctor can select embryos free from
What are the indications of PGD?
Your doctor may prescribe PGD in case of family history of:
- Cystic fibrosis
- Fragile X syndrome
- Spinal muscular dystrophies (SMA)
- Duchenne muscular dystrophy (DMD)
- Huntington disease.
- Alpha Thalassemia
- Glycine encephalopathy
- Familial Mediterranean fever
- Polycystic kidney
What is the ERA test?
ERA Test is also called Endometrial Receptivity Analysis test. It determines whether the
endometrium of the pregnant woman is receiving the embryos at an accurate time or not.
ERA can maximize the chances of a successful pregnancy